Discordance between Traditional Pathologic and Energy Metabolic Changes in Very Early Alzheimer's Disease: Pathophysiological Implications

Discordance between traditional pathologic and energy metabolic changes in very early Alzheimer's disease. Pathophysiological implications.

These results suggest that neither the loss of entorhinal efferents nor cholinergic deficit explains all the metabolic features seen in very early AD. Given recent immunohistological evidence of massive glutamatergic synaptic alteration in early AD cortex and insights into neuronal and glial mechanisms of glucose metabolism, very early metabolic changes in AD probably reflect a significant impa...

Metabolic Bone Disease in Very Low-Birth-Weight Neonates

Background: Metabolic bone diseases (MBD), including rickets and osteopenia, are important neonatal complications among preterm infants. This study aimed to determine the prevalence and risk factors of MBD in neonates with very low birth weight (VLBW). Methods: This prospective study was conducted on VLBW infants from January 2012 to July 2013. Inclusion criteria were birth weight of ≤1500 g a...

Pathophysiological Changes in Early Endometriosis

Early influences in childhood obesity--implications for adult metabolic disease.

1Department of Paediatrics, Khoo Teck Puat-University Children’s Medical Institute, National University Hospital, Singapore Address for Correspondence: Dr Loke Kah Yin, Department of Paediatrics, Khoo Teck Puat-University Children’s Medical Institute, National University Hospital, 5 Lower Kent Ridge road, Singapore 119074. Email: [email protected] Early Infl uences in Childhood Obesity—K...

Linkage of Parkinson’s disease in two very early onset siblings to a locus on chromosome 1

Parkinson’s disease (PD) is a prevalent neurodegenerative disease that usually affects individuals over 50 years of age. Age at onset in a small subset of PD cases is considerably lower, and these are considered early-onset PD (EOPD) patients. Most PD cases appear sporadic, but approximately 15% are familial, and some of the familial cases exhibit Mendelian inheritance. Genetic analysis of fami...